FEATURES

FAMILY

DESCRIPTION

Also known as TTK_HUMAN, TTK, MPS1, MPS1L1. Phosphorylates proteins on serine, threonine, and tyrosine (PubMed:18243099, PubMed:29162720). Probably associated with cell proliferation (PubMed:18243099). Phosphorylates MAD1L1 to promote mitotic checkpoint signaling (PubMed:29162720). Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint (PubMed:18243099). Interacts with TPR; the interactions occurs in a microtubule-independent manner (PubMed:19273613). Interacts with MAD1L1 and MAD2L1 (PubMed:29162720).

Also known as TTK_HUMAN, TTK, MPS1, MPS1L1. Phosphorylates proteins on serine, threonine, and tyrosine (PubMed:18243099, PubMed:29162720). Probably associated with cell proliferation (PubMed:182 ...

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

TTK

Mutations

Mutation(s) distribution

Mutations table