FEATURES

FAMILY

DESCRIPTION

Also known as HCP3L_CAEEL, cpar-1. Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division. Not required for chromosome segregation during meiosis. Forms a nucleosome-like histone octamer containing two molecules each of H2A, H2B, cpar-1 and H4 assembled in one cpar-1-H4 heterotetramer and two H2A-H2B heterodimers.

EXTERNAL LINKS

uniprot
enzyme classification

cpar-1

Histone H3-like centromeric protein cpar-1

cpar-1

Structural Ligandability

Domains Chains

Distribution