FEATURES

FAMILY

DESCRIPTION

Also known as PROF2_HUMAN, PFN2. Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio (PubMed:7758455). Interacts with PFN2 (By similarity).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

PFN2

Profilin-2

PFN2

Molecular Synopsis