FEATURES

FAMILY

DESCRIPTION

Also known as RFC2_HUMAN, RFC2. The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. This subunit binds ATP (By similarity). Heterotetramer of subunits RFC2, RFC3, RFC4 and RFC5 that can form a complex either with RFC1 or with RAD17. The former interacts with PCNA in the presence of ATP, while the latter has ATPase activity but is not stimulated by PCNA. RFC2 also interacts with PRKAR1A; the complex may be involved in cell survival (PubMed:15655353). Interacts with DDX11 (PubMed:18499658).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

RFC2

Mutations

Mutation(s) distribution

Mutations table