FEATURES

FAMILY

DESCRIPTION

Also known as ADA1A_HUMAN, ADRA1A, ADRA1C. This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes. Homo- and heterooligomer. Heterooligomerizes with ADRA1B homooligomers in cardiac myocytes (PubMed:22120526). Interacts with CAVIN4 (PubMed:24567387).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

ADRA1A

Alpha-1A adrenergic receptor

ADRA1A

Molecular Synopsis