FEATURES

FAMILY

DESCRIPTION

Also known as PE2R4_HUMAN, PTGER4, PTGER2. Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function. Interacts with FEM1A.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

PTGER4

Prostaglandin E2 receptor EP4 subtype

PTGER4

Molecular Synopsis