FEATURES

DESCRIPTION

Also known as FOXA3_MOUSE, Foxa3, Hnf3g, Tcf-3g, Tcf3g. Transcription factor that is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites (By similarity). Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; activates GLUT2 transcription. Involved in regulation of neuronal-specific transcription. Involved in regulation of spermatogenesis; required for the maintenance of the testicular germ cell population and male fertility. Interacts with FOXA2.

EXTERNAL LINKS

Foxa3

Hepatocyte nuclear factor 3-gamma

Foxa3

Molecular Synopsis