FEATURES

FAMILY

DESCRIPTION

Also known as ACTN2_HUMAN, ACTN2. F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. Homodimer; antiparallel. Also forms heterodimers with ACTN3. Interacts with ADAM12, MYOZ1, MYOZ2 and MYOZ3. Interacts via its C-terminal region with the LDB3 PDZ domain. Interacts with XIRP2. Interacts with DST isoform 1 (via N-terminus). Interacts with PARVB. Interacts with SYNPO2.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

ACTN2

Alpha-actinin-2

ACTN2

Molecular Synopsis