FEATURES

FAMILY

DESCRIPTION

Also known as SOAT1_HUMAN, SOAT1, ACACT, ACACT1, ACAT, ACAT1, SOAT, STAT. Catalyzes the formation of fatty acid-cholesterol esters, which are less soluble in membranes than cholesterol (PubMed:16154994, PubMed:16647063, PubMed:9020103, PubMed:32433614, PubMed:32433613, PubMed:32944968). Plays a role in lipoprotein assembly and dietary cholesterol absorption (PubMed:16154994, PubMed:9020103). Utilizes oleoyl-CoA ((9Z)-octadecenoyl-CoA) preferentially as susbstrate: shows a higher activity towards an acyl-CoA substrate with a double bond at the delta-9 position (9Z) than towards saturated acyl-CoA or an unsaturated acyl-CoA with a double bond at the delta-7 (7Z) or delta-11 (11Z) positions (PubMed:11294643, PubMed:32433614). Homotetramer; composed of two homodimers (PubMed:32433614, PubMed:32433613). Interacts with UBIAD1 (PubMed:23169578).

Also known as SOAT1_HUMAN, SOAT1, ACACT, ACACT1, ACAT, ACAT1, SOAT, STAT. Catalyzes the formation of fatty acid-cholesterol esters, which are less soluble in membranes than cholesterol (PubMed ...

EXTERNAL LINKS

SOAT1

Mutations

Mutation(s) distribution

Mutations table