FEATURES

FAMILY

DESCRIPTION

Also known as NDK_YEAST, YNK1, NDK1, YNK. Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (PubMed:5793714). Required for repair of UV radiation- and etoposide-induced DNA damage (PubMed:18983998). Homohexamer and homotetramer. Interacts with TOM40 preferentially in an unfolded, unphosphorylated form.

EXTERNAL LINKS

uniprot
enzyme classification

YNK1

Nucleoside diphosphate kinase

YNK1

Molecular Synopsis