FEATURES

FAMILY

ligand-gated ion channel (TC 1.A.9) family

DESCRIPTION

Also known as ACHA7_HUMAN, CHRNA7, NACHRA7. After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin. Homopentamer (By similarity). Interacts with RIC3; which is required for proper folding and assembly (PubMed:15504725, PubMed:16120769). Interacts with LYPD6 (PubMed:27344019). Interacts with the alpha-conotoxin RgIA (By similarity). Interacts with alpha-conotoxins ImI and ImII (PubMed:15609996). Interacts with CANX (PubMed:32783947).

EXTERNAL LINKS

CHRNA7

Mutations

Mutation(s) distribution

Mutations table