L1 (Pre-hexon-linking protein IIIa)

FEATURES

FAMILY

adenoviridae hexon-linking protein IIIa family

DESCRIPTION

Also known as CAP3_ADE12, L1. Structural component of the virion that acts as a cement protein on the capsid exterior which mediates the interactions between the hexons, including the peripentonal hexons, and reaches all the way to the penton vertices. Two hexon linking proteins IIIa, one from each facet, stabilize the unique edge interface between a pair of facets. As the virus enters the host cell, hexon linking proteins IIIa are shed concomitant with virion acidification in the endosome. During virus assembly, seems to play a role in the serotype specificity of the packaging of viral DNA via its interaction with packaging protein 3. Interacts with hexon proteins; this interaction tethers the peripentonal hexons to hexons situated in the facet. Interacts with the penton protein (via N-terminus). Interacts with packaging protein 3; this interaction is required to promote correct genome packaging.

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EXTERNAL LINKS

L1

Pre-hexon-linking protein IIIa

LIGANDABILITY MUTATIONS

L1

Molecular Synopsis