FEATURES

FAMILY

DESCRIPTION

Also known as ICP34_HHV1N, RL1, ICP34.5. Plays essential roles in viral nuclear egress to mediate capsid transit across the nuclear membrane and also in the inhibition of host immune response. Facilitates nuclear egress cooperatively with host C1QBP and protein kinase C/PKC to induce lamin A/C phosphorylation and subsequent reorganization. In turn, lamina disassembles and nuclear egress occurs. Recruits the serine/threonine protein phosphatase PPP1CA/PP1-alpha to dephosphorylate the translation initiation factor eIF-2A, thereby couteracting the host shutoff of protein synthesis involving double-stranded RNA-dependent protein kinase EIF2AK2/PKR. In turn, controls host IRF3 activation and subsequently inhibits host interferon response. Controls the DNA sensing pathway by interacting with and inhibiting host STING/TMEM173. Also down-modulates the host MHC class II proteins cell surface expression. Acts as a neurovirulence factor that has a profound effect on the growth of the virus in central nervous system tissue, by interqcting with host BECN1 and thereby antagonizing the host autophagy response. Interacts with human PPP1CA to form a high-molecular-weight complex that dephosphorylates eIF2-alpha (By similarity). Binds to proliferating cell nuclear antigen (PCNA), which may release host cells from growth arrest and facilitate viral replication. Interacts (via N-terminus) with host C1QBP and PRKCA. Interacts with protein UL31. Interacts with host TBK1. Interacts with host STING/TMEM173; this interaction inhibits the intracellular DNA sensing pathway. Interacts with host BECN1; this interaction modulates host autophagy (By similarity).

EXTERNAL LINKS

RL1

Neurovirulence factor ICP34.5

RL1

Molecular Synopsis