FEATURES

FAMILY

DESCRIPTION

Also known as PANZ_ECOLI, panZ, panM, yhhK. Controls both the activation and catalytic activity of PanD in a coenzyme A (CoA)-dependent fashion. Binding of CoA or a derivative to PanZ leads to interaction with PanD, which promotes the processing and activation of pro-PanD, and subsequent substrate-mediated inhibition of the active form of PanD (PubMed:23170229, PubMed:25910242). Inhibition of PanD activity is probably the primary metabolic role of PanZ, allowing negative feedback regulation of pantothenate biosynthesis by CoA (PubMed:25910242). Interacts with PanD in the presence of CoA (PubMed:23170229, PubMed:22940551, PubMed:25910242). Forms a heterooctameric complex composed of four PanD subunits and four PanZ subunits (PubMed:22940551, PubMed:25910242). Monomer in solution (PubMed:22940551).

EXTERNAL LINKS

panZ

PanD regulatory factor

panZ

Molecular Synopsis