FEATURES

FAMILY

DESCRIPTION

Also known as LON1_BACSU, lon1, lonA. ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity). Has been implicated in preventing sigma(G) activity under non-sporulation conditions. Homohexamer. Organized in a ring with a central cavity (By similarity). Exists as a mixture of small oligomeric species in solution.

EXTERNAL LINKS

lon1

Mutations

Mutation(s) distribution

Mutations table