FEATURES

FAMILY

DESCRIPTION

Also known as TRM7_YEAST, TRM7. Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of tRNA(Phe), tRNA(Trp) and tRNA(Leu(UAA)). Requires TRM732 for methylation of the cytidine at position 32 and RTT10/TRM734 for methylation of the nucleotides at position 34 in substrate tRNAs. Lack of either of these modifications in tRNA(Phe) reduces formation of wybutosine from 1-methylguanosine at position 37. Interacts with TRM732; for 2'-O-methylation of cytidine 32 in substrate tRNAs. Interacts with RTT10/TRM734; for 2'-O-methylation of position 34 in substrate tRNAs.

EXTERNAL LINKS

uniprot
enzyme classification

TRM7

tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase

TRM7

Molecular Synopsis