FEATURES

DESCRIPTION

Also known as SEC72_YEAST, SEC72, SEC67, SIM2. Acts as non-essential component of the Sec62/63 complex which is involved in SRP-independent post-translational translocation across the endoplasmic reticulum (ER) and functions together with the Sec61 complex and KAR2 in a channel-forming translocon complex. A cycle of assembly and disassembly of Sec62/63 complex from SEC61 may govern the activity of the translocon. SEC72 may be involved in signal peptide recognition for a defined subset of leader peptides, or may increase the efficiency of unusual or 'difficult' secretory precursors to the translocation pore, it may be that this protein binds charged leader peptides to the membrane until they engage the translocation apparatus. Component of the heterotetrameric Sec62/63complex composed of SEC62, SEC63, SEC71 and SEC72. The Sec62/63 complex associates with the Sec61 complex to form the Sec complex. May interact with protein YLR301W. Part of a complex consisting of KAR2, SEC63, SEC66 and SEC72.

EXTERNAL LINKS

SEC72

Mutations

Mutation(s) distribution

Mutations table