FEATURES

FAMILY

DESCRIPTION

Also known as MMP12_HUMAN, MMP12, HME. May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

MMP12

Macrophage metalloelastase

MMP12

Molecular Synopsis