FEATURES

FAMILY

DESCRIPTION

Also known as RL13A_HUMAN, RPL13A. Associated with ribosomes but is not required for canonical ribosome function and has extra-ribosomal functions. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the ribosome and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation. In the GAIT complex interacts with m7G cap-bound eIF4G at or near the eIF3-binding site and blocks the recruitment of the 43S ribosomal complex. Involved in methylation of rRNA. Component of the 60S ribosome. Component of the GAIT complex. Interacts with EIF4G1.

EXTERNAL LINKS

RPL13A

60S ribosomal protein L13a

RPL13A

Molecular Synopsis