FEATURES

DESCRIPTION

Also known as NU159_YEAST, NUP159, NUP158, RAT7. Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope (GSP1 and GSP2 GTPases associated predominantly with GTP in the nucleus, with GDP in the cytoplasm). NUP159 plays an important role in several nuclear export pathways including poly(A)+ RNA, pre-ribosome, and protein export. Component of the nuclear pore complex (NPC) (PubMed:17546040). NPC constitutes the exclusive means of nucleocytoplasmic transport. NPCs allow the passive diffusion of ions and small molecules and the active, nuclear transport receptor-mediated bidirectional transport of macromolecules such as proteins, RNAs, ribonucleoparticles (RNPs), and ribosomal subunits across the nuclear envelope. Due to its 8-fold rotational symmetry, all subunits are present with 8 copies or multiples thereof. Part of the NUP82 subcomplex, interacts with NUP82 through its C-terminal coiled coil (PubMed:9736720, PubMed:17546040, PubMed:23223634, PubMed:25646085). This subcomplex is the base for interactions with NUP116 and GLE2, with NUP42 and GLE1 and with DYN2 (PubMed:17546040, PubMed:23223634). Interacts directly with DYN2 (PubMed:17546040, PubMed:23223634, PubMed:25646085). Interacts through its FG repeats with karyopherins, such as heterodimeric mRNA transport factor MEX67/MTR2, CRM1 (XPO1), and PSE1 (GSP1-GDP dependent). Interaction with CRM1 (XPO1) is GSP1-GTP dependent and stimulated by RNA1. NUP159 also interacts with GLE1 and the ATP-dependent RNA helicase DBP5.

Also known as NU159_YEAST, NUP159, NUP158, RAT7. Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of ...

EXTERNAL LINKS

NUP159

Mutations

Mutation(s) distribution

Mutations table