FEATURES

DESCRIPTION

Also known as VID28_YEAST, VID28, GID5. Required for the adaptation to the presence of glucose in the growth medium; mediates the degradation of enzymes involved in gluconeogenesis when cells are shifted to glucose-containing medium (PubMed:12686616). Required for proteasome-dependent catabolite degradation of fructose-1, 6-bisphosphatase (FBP1) (PubMed:12686616). Identified in the GID complex. In the absence of glucose, the complex contains VID30/GID1, the E3 ubiquitin-ligase RMD5/GID2, VID28/GID5, GID7, GID8, and FYV10/GID9. When cells are shifted to glucose-containing medium, VID24/GID4 is induced and becomes part of the complex (PubMed:22645139). Within the GID complex, interacts directly with RMD5/GID2 and FYV10/GID9, and recruits VID24/GID4 to the complex when cells are shifted to glucose-containing medium (PubMed:22645139).

EXTERNAL LINKS

VID28

Vacuolar import and degradation protein 28

VID28

Molecular Synopsis