FEATURES

FAMILY

class-II aminoacyl-tRNA synthetase family

DESCRIPTION

Also known as GARS_HUMAN, GARS1, GARS. Catalyzes the ATP-dependent ligation of glycine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (Gly-AMP) (PubMed:17544401, PubMed:28675565, PubMed:24898252). Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs. Thereby, may play a special role in Ap4A homeostasis (PubMed:19710017). Homodimer.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

GARS1

Glycine--tRNA ligase

GARS1

Molecular Synopsis