FEATURES

FAMILY

DESCRIPTION

Also known as ACADM_PIG, ACADM. Medium-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats (PubMed:3233192). The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA (PubMed:3233192). Electron transfer flavoprotein (ETF) is the electron acceptor that transfers electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) (By similarity). Among the different mitochondrial acyl-CoA dehydrogenases, medium-chain specific acyl-CoA dehydrogenase acts specifically on acyl-CoAs with saturated 6 to 12 carbons long primary chains (By similarity). Homotetramer (PubMed:12966080). Interacts with the heterodimeric electron transfer flavoprotein ETF (By similarity).

EXTERNAL LINKS

ACADM

Medium-chain specific acyl-CoA dehydrogenase, mitochondrial

ACADM

Molecular Synopsis