FEATURES

FAMILY

NADH:flavin oxidoreductase/NADH oxidase family

DESCRIPTION

Also known as OYE3_YEAST, OYE3. Flavin-dependent enoate reductase that catalyzes the chemo- and stereoslective hydrogenation of electron-poor alkenes. The enzyme is reduced by NADPH, and oxygen, quinones, and alpha, beta-unsaturated aldehydes and ketones can act as electron acceptors to complete catalytic turnover. The physiological oxidant remains elusive (By similarity). Has a prooxidant activity, increasing reactive oxygen species (ROS) levels when overexpressed. Formation of OYE2-OYE3 heterodimers contribute to the induction of programmed cell death upon oxidative stress (PubMed:17897954). Homodimer or heterodimer with OYE2.

EXTERNAL LINKS

uniprot
enzyme classification

OYE3

NADPH dehydrogenase 3

OYE3

Molecular Synopsis