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FEATURES

FAMILY

short-chain dehydrogenases/reductases (SDR) family

DESCRIPTION

Also known as PTR1_LEITA, PTR1, LTDH. Exhibits a NADPH-dependent biopterin reductase activity. Has good activity with folate and significant activity with dihydrofolate and dihydrobiopterin, but not with quinonoid dihydrobiopterin. Confers resistance to methotrexate (MTX). Homotetramer.

Also known as PTR1_LEITA, PTR1, LTDH. Exhibits a NADPH-dependent biopterin reductase activity. Has good activity with folate and significant activity with dihydrofolate and dihydrobiopterin, but no ...

EXTERNAL LINKS

uniprot
enzyme classification

PTR1

Pteridine reductase 1

Mutations

Mutation(s) distribution

Mutations table

Search Mutation

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