FEATURES

FAMILY

dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family

DESCRIPTION

Also known as EAA1_HUMAN, SLC1A3, EAAT1, GLAST, GLAST1. Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:7521911, PubMed:8123008, PubMed:20477940, PubMed:26690923, PubMed:28032905, PubMed:28424515). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion (PubMed:20477940). Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (PubMed:20477940). Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate (By similarity). Homotrimer (PubMed:28424515). Interacts with isoform 2 of BSG (By similarity).

Also known as EAA1_HUMAN, SLC1A3, EAAT1, GLAST, GLAST1. Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed ...

EXTERNAL LINKS

SLC1A3

Mutations

Mutation(s) distribution

Mutations table