FEATURES

FAMILY

DESCRIPTION

Also known as TRNL_CANAL, LIG1, RLG1, TRL1. One of the two proteins required for the splicing of precursor tRNA molecules containing introns. The ligation activity requires three enzymatic activities: phosphorylation of the 5' terminus of the 3' half-tRNA in the presence of ATP, opening of the 2'3'-cyclic phosphodiester bond of the 5' half-tRNA leaving a 2'-phosphomonoester and ligation of the two tRNA halves in an ATP-dependent reaction.

EXTERNAL LINKS

uniprot
enzyme classification

LIG1

tRNA ligase

LIG1

Molecular Synopsis