FEATURES

FAMILY

DESCRIPTION

Also known as GRK6_HUMAN, GRK6, GPRK6. Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (By similarity). Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro). Interacts with GIT1.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

GRK6

Mutations

Mutation(s) distribution

Mutations table