FEATURES

FAMILY

DESCRIPTION

Also known as NR4A2_HUMAN, NR4A2, NOT, NURR1, TINUR. Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons (By similarity). Interacts with SFPQ, NCOR2, SIN3A and HADC1. The interaction with NCOR2 increases in the absence of PITX3. Interacts with PER2 (By similarity).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

NR4A2

Nuclear receptor subfamily 4 group A member 2

NR4A2

Molecular Synopsis