FEATURES

FAMILY

DESCRIPTION

Also known as THI5_YEAST, THI5, MOL2. Responsible for the formation of the pyrimidine heterocycle in the thiamine biosynthesis pathway. Catalyzes the formation of hydroxymethylpyrimidine phosphate (HMP-P) from histidine and pyridoxal phosphate (PLP). The protein uses PLP and the active site histidine to form HMP-P, generating an inactive enzyme. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. Homodimer.

EXTERNAL LINKS

uniprot
enzyme classification

THI5

4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase THI5

THI5

Molecular Synopsis