FEATURES

FAMILY

DESCRIPTION

Also known as VTC4_YEAST, VTC4, PHM3. Component of the vacuolar transporter chaperone (VTC) complex, which plays a role in vacuolar membrane fusion (PubMed:12584253, PubMed:11102525, PubMed:11823419). Required for SEC18/NSF activity in SNARE priming, membrane binding of LMA1 and V(0) trans-complex formation (PubMed:11823419). Binds inositol hexakisphosphate (Ins6P) and similar inositol polyphosphates, such as 5-diphospho-inositol pentakisphosphate (5-InsP7); these are important intracellular signaling molecules (PubMed:27080106). Inositol polyphosphate binding promotes vacuolar polyphosphate synthesis (PubMed:27080106). The VTC complex is an integral membrane heterooligomer composed of VTC1, VTC2, VTC3 and VTC4. The complex interacts with the v-SNARE NYV1 and with the V(0) subunit of V-ATPase VPH1.

Also known as VTC4_YEAST, VTC4, PHM3. Component of the vacuolar transporter chaperone (VTC) complex, which plays a role in vacuolar membrane fusion (PubMed:12584253, PubMed:11102525, PubMed:11823 ...

EXTERNAL LINKS

VTC4

Mutations

Mutation(s) distribution

Mutations table