FEATURES

FAMILY

F-actin-capping protein alpha subunit family

DESCRIPTION

Also known as CAZA2_HUMAN, CAPZA2. F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Heterodimer of an alpha and a beta subunit. Component of the WASH complex, composed of F-actin-capping protein subunit alpha (CAPZA1, CAPZA2 or CAPZA3), F-actin-capping protein subunit beta (CAPZB), WASH (WASHC1, WASH2P, WASH3P, WASH4P, WASH5P or WASH6P), WASHC2 (WASHC2A or WASHC2C), WASHC3, WASHC4 and WASHC5. Interacts with RCSD1/CAPZIP. Directly interacts with CRACD; this interaction decreases binding to actin (PubMed:30361697).

EXTERNAL LINKS

CAPZA2

F-actin-capping protein subunit alpha-2

Structural Ligandability

Domains Chains

0 chains assessed

1 chain not associated with a domain

CAPZA2

Structural Ligandability

Domains Chains

Distribution