FEATURES

FAMILY

carnitine/choline acetyltransferase family

DESCRIPTION

Also known as CACP_MOUSE, Crat. Catalyzes the reversible transfer of acyl groups from carnitine to coenzyme A (CoA) and regulates the acyl-CoA/CoA ratio. Also plays a crucial role in the transport of fatty acids for beta-oxidation. Responsible for the synthesis of short- and branched-chain acylcarnitines. Active towards some branched-chain amino acid oxidation pathway (BCAAO) intermediates. Trans-2-enoyl-CoAs and 2-methylacyl-CoAs are poor substrates. Monomer.

EXTERNAL LINKS

uniprot
enzyme classification

Crat

Mutations

Mutation(s) distribution

Mutations table