FEATURES

DESCRIPTION

Also known as PI42A_HUMAN, PIP4K2A, PI5P4KA, PIP5K2, PIP5K2A. Catalyzes the phosphorylation of phosphatidylinositol 5-phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4, 5-bisphosphate (PtdIns(4, 5)P2) (PubMed:9367159, PubMed:23326584). Has both ATP- and GTP-dependent kinase activities (PubMed:26774281). May exert its function by regulating the levels of PtdIns5P, which functions in the cytosol by increasing AKT activity and in the nucleus signals through ING2 (PubMed:18364242). May regulate the pool of cytosolic PtdIns5P in response to the activation of tyrosine phosphorylation (By similarity). Required for lysosome-peroxisome membrane contacts and intracellular cholesterol transport through modulating peroxisomal PtdIns(4, 5)P2 level (PubMed:29353240). In collaboration with PIP4K2B, has a role in mediating autophagy in times of nutrient stress (By similarity). Required for autophagosome-lysosome fusion and the regulation of cellular lipid metabolism (PubMed:31091439). May be involved in thrombopoiesis, and the terminal maturation of megakaryocytes and regulation of their size (By similarity). Negatively regulates insulin signaling through a catalytic-independent mechanism (PubMed:31091439). PIP4Ks interact with PIP5Ks and suppress PIP5K-mediated PtdIns(4, 5)P2 synthesis and insulin-dependent conversion to PtdIns(3, 4, 5)P3 (PubMed:31091439). Homodimer (PubMed:32130941). Interacts with PIP4K2B; the interaction may regulate localization to the nucleus (PubMed:20583997). Probably interacts with PIP5K1A; the interaction inhibits PIP5K1A kinase activity (By similarity).

Also known as PI42A_HUMAN, PIP4K2A, PI5P4KA, PIP5K2, PIP5K2A. Catalyzes the phosphorylation of phosphatidylinositol 5-phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form ...

EXTERNAL LINKS

PIP4K2A

Mutations

Mutation(s) distribution

Mutations table