FEATURES

FAMILY

dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family

DESCRIPTION

Also known as EAA4_HUMAN, SLC1A6, EAAT4. Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:7791878). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion. Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (By similarity). Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate (Probable). Homotrimer.

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EXTERNAL LINKS

SLC1A6

Excitatory amino acid transporter 4

ligandability Mutations

SLC1A6

Molecular Synopsis