FEATURES

FAMILY

DESCRIPTION

Also known as TXI92_DIGCA, TXI92. Insecticidal toxin (PubMed:8541888, PubMed:8896202). This toxin promotes opening of insect Nav channels. The toxin binds to the S1-S2 and S3-S4 loops in the domain II voltage-sensor of insect Nav channels (i.e., receptor site 4). The American cockroach P.americana is largely resistant to the effects of this toxin due to an unusual sequence within the domain II S1-S2 loop. In vivo, paralyzes lepidopteran and dipteran larvae. Paralyzed insects ultimately die from secondary effects of starvation and dehydration (PubMed:25014760).

EXTERNAL LINKS

uniprot
enzyme classification

TXI92

Beta-diguetoxin-Dc1a

TXI92

Molecular Synopsis