FEATURES

FAMILY

DESCRIPTION

Also known as NRAM1_HUMAN, SLC11A1, LSH, NRAMP, NRAMP1. Divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Macrophage-specific membrane transport function. Controls natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis of its protective enzymes.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

SLC11A1

Natural resistance-associated macrophage protein 1

SLC11A1

Molecular Synopsis