FEATURES

DESCRIPTION

Also known as FAS_HUMAN, FASN, FAS. Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain. Homodimer which is arranged in a head to tail fashion (PubMed:17618296, PubMed:18022563, Ref.33). Interacts with CEACAM1; this interaction is insulin and phosphorylation-dependent; reduces fatty-acid synthase activity.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

FASN

Mutations

Mutation(s) distribution

Mutations table