FEATURES

FAMILY

Classic translation factor GTPase family

DESCRIPTION

Also known as EFTU_HUMAN, TUFM. Promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Plays also a role in the regulation of autophagy and innate immunity. Recruits ATG5-ATG12 and NLRX1 at mitochondria and serves as a checkpoint of the RIG-I/DDX58-MAVS pathway. In turn, inhibits RLR-mediated type I interferon while promoting autophagy. Interacts with NLRX1 (PubMed:22749352). Interacts with ATG16L1 (PubMed:22749352).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

TUFM

Mutations

Mutation(s) distribution

Mutations table