FEATURES

FAMILY

DESCRIPTION

Also known as HXA1_HUMAN, HOXA1, HOX1F. Sequence-specific transcription factor (By similarity). Regulates multiple developmental processes including brainstem, inner and outer ear, abducens nerve and cardiovascular development and morphogenesis as well as cognition and behavior (PubMed:16155570). Also part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures. Seems to act in the maintenance and/or generation of hindbrain segments (By similarity). Activates transcription in the presence of PBX1A and PKNOX1 (By similarity). Interacts with OGT (via TPR repeats domain); the interaction takes place mainly in the nucleus (By similarity). Forms a DNA-binding heterodimer with transcription factor PBX1 (PubMed:9191052).

Also known as HXA1_HUMAN, HOXA1, HOX1F. Sequence-specific transcription factor (By similarity). Regulates multiple developmental processes including brainstem, inner and outer ear, abducens nerve ...

EXTERNAL LINKS

HOXA1

Homeobox protein Hox-A1

HOXA1

Molecular Synopsis