FEATURES

FAMILY

DESCRIPTION

Also known as CLK3_HUMAN, CLK3. Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Phosphorylates SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

CLK3

Mutations

Mutation(s) distribution

Mutations table