FEATURES

FAMILY

DESCRIPTION

Also known as PLGF_HUMAN, PGF, PGFL, PLGF. Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. It binds to the receptor FLT1/VEGFR-1. Isoform PlGF-2 binds NRP1/neuropilin-1 and NRP2/neuropilin-2 in a heparin-dependent manner. Also promotes cell tumor growth. Antiparallel homodimer; disulfide-linked. Also found as heterodimer with VEGFA/VEGF. Isoform PlGF-3 is found both as homodimer and as monomer.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

PGF

Placenta growth factor

PGF

Molecular Synopsis