FEATURES

DESCRIPTION

Also known as RGS3_HUMAN, RGS3. Down-regulates signaling from heterotrimeric G-proteins by increasing the GTPase activity of the alpha subunits, thereby driving them into their inactive GDP-bound form. Down-regulates G-protein-mediated release of inositol phosphates and activation of MAP kinases. Binds EFNB1 and EFNB2 (By similarity). Binds the GNB1-GNG2 heterodimer.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

RGS3

Regulator of G-protein signaling 3

RGS3

Molecular Synopsis