FEATURES

FAMILY

5-formyltetrahydrofolate cyclo-ligase family

DESCRIPTION

Also known as MTHFS_HUMAN, MTHFS. Contributes to tetrahydrofolate metabolism. Helps regulate carbon flow through the folate-dependent one-carbon metabolic network that supplies carbon for the biosynthesis of purines, thymidine and amino acids. Catalyzes the irreversible conversion of 5-formyltetrahydrofolate (5-FTHF) to yield 5, 10-methenyltetrahydrofolate. Monomer.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

MTHFS

5-formyltetrahydrofolate cyclo-ligase

Mutations

Mutation(s) distribution

Mutations table

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