FEATURES

FAMILY

DESCRIPTION

Also known as IMDH_TRIFO, IMPDH. Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. Homotetramer.

EXTERNAL LINKS

uniprot
enzyme classification

IMPDH

Inosine-5'-monophosphate dehydrogenase

Mutations

Mutation(s) distribution

Mutations table

Search Mutation