FEATURES

FAMILY

short-chain dehydrogenases/reductases (SDR) family

DESCRIPTION

Also known as DHI1_MOUSE, Hsd11b1, Hsd11. Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone (By similarity). Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7-ketocholesterol to 7-beta-hydroxycholesterol (By similarity). Homodimer.

EXTERNAL LINKS

uniprot
enzyme classification

Hsd11b1

Corticosteroid 11-beta-dehydrogenase isozyme 1

Mutations

Mutation(s) distribution

Mutations table

Search Mutation