FEATURES

FAMILY

DESCRIPTION

Also known as END8_ECOLI, nei. Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5, 6-dihydrouracil and 5, 6-dihydrothymine. Acts on DNA bubble and 3'-fork structures, suggesting a role in replication-associated DNA repair. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.

EXTERNAL LINKS

uniprot
enzyme classification

nei

Endonuclease 8

nei

Molecular Synopsis