FEATURES

FAMILY

DESCRIPTION

Also known as F10A1_HUMAN, ST13, AAG2, FAM10A1, HIP, SNC6. One HIP oligomer binds the ATPase domains of at least two HSC70 molecules dependent on activation of the HSC70 ATPase by HSP40. Stabilizes the ADP state of HSC70 that has a high affinity for substrate protein. Through its own chaperone activity, it may contribute to the interaction of HSC70 with various target proteins (By similarity). Homotetramer. Interacts with HSC70 as well as DNAJ homologs and HSP90 (By similarity). Interacts (via the C-terminus 303- 319 AA) with GRK5.

Also known as F10A1_HUMAN, ST13, AAG2, FAM10A1, HIP, SNC6. One HIP oligomer binds the ATPase domains of at least two HSC70 molecules dependent on activation of the HSC70 ATPase by HSP40. Stabiliz ...

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

ST13

Hsc70-interacting protein

ST13

Molecular Synopsis