FEATURES

FAMILY

DESCRIPTION

Also known as TSPO_MOUSE, Tspo, Bzrp, Mbr. Can bind protoporphyrin IX and may play a role in the transport of porphyrins and heme (By similarity). Was initially identified as peripheral-type benzodiazepine receptor; can also bind isoquinoline carboxamides. Promotes the transport of cholesterol across mitochondrial membranes and may play a role in lipid metabolism (PubMed:9832438, PubMed:24814875), but its precise physiological role is controversial. According to some reports, it is not required for steroid hormone biosynthesis (PubMed:24174323, PubMed:24936060). Interacts with TSPOAP1. Interacts with MOST-1. May interact with STAR.

EXTERNAL LINKS

uniprot
enzyme classification

Tspo

Mutations

Mutation(s) distribution

Mutations table