FEATURES

FAMILY

DESCRIPTION

Also known as ORC5_YEAST, ORC5. Component of the origin recognition complex (ORC) that binds origins of replication. It has a role in both chromosomal replication and mating type transcriptional silencing. Binds to the ARS consensus sequence (ACS) of origins of replication. This subunit is a candidate for the mediation of ATP-dependent binding of ORC to origins. May also be a substrate targeting component of a cullin-RING-based E3 ubiquitin-protein ligase complex RTT101(MMS1-ORC5). Component of the origin recognition complex (ORC) composed of at least ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. Interacts with ORC6. Component of a cullin-RING ligase (CRL)-like complex composed of at least the cullin RTT101, a linker protein MMS1, and the potential substrate receptor ORC5. Interacts with RTT101 and MMS1.

EXTERNAL LINKS

ORC5

Mutations

Mutation(s) distribution

Mutations table